Florence is a classic for a reason. The city itself is gorgeous, the weather is mild, the food and wine are delicious. Hannes was in Florence for a conference back in October, so I took the chance to fly down for a 4-day weekend and bask in the sunshine.
If you happen to be in Florence, you should absolutely go to the restaurant Fagioli, Corso de' Tintori 47r. The kicker is, it's only open Monday-Friday...we were there on Friday night and I totally would've gone back Saturday night if it had been open. Homey, delicious Italian food, very friendly, plus they will plop a bottle (or more) of Chianti on the table and then only charge you for what you drink. Incidentally, I found the restaurant through the Eat Florence App for ipad, which foodies would enjoy. For museum-going we liked the free Rick Steeves audio guides, but I would recommend less museums and more wandering...plus lots of stops for gelatto/espresso/vino/paninis - whatever your favorite may be.